This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2w2j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:41, 13 December 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2w2j' size='340' side='right'caption='[[2w2j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2w2j' size='340' side='right'caption='[[2w2j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2w2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2J FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2w2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2J FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2j OCA], [https://pdbe.org/2w2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2j RCSB], [https://www.ebi.ac.uk/pdbsum/2w2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2j OCA], [https://pdbe.org/2w2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2j RCSB], [https://www.ebi.ac.uk/pdbsum/2w2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2j ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3) [MIM:[https://omim.org/entry/613227 613227]]. CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.
+
[https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN] Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3) [MIM:[https://omim.org/entry/613227 613227]. CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Does not have a carbonic anhydrase catalytic activity.
+
[https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN] Does not have a carbonic anhydrase catalytic activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 24: Line 24:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Carbonate dehydratase]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Arrowsmith C]]
-
[[Category: Bountra, C]]
+
[[Category: Bountra C]]
-
[[Category: Delft, F von]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A]]
+
[[Category: Filippakopoulos P]]
-
[[Category: Filippakopoulos, P]]
+
[[Category: King ONF]]
-
[[Category: King, O N.F]]
+
[[Category: Kochan G]]
-
[[Category: Kochan, G]]
+
[[Category: Kramm A]]
-
[[Category: Kramm, A]]
+
[[Category: Muniz JRC]]
-
[[Category: Muniz, J R.C]]
+
[[Category: Oppermann U]]
-
[[Category: Oppermann, U]]
+
[[Category: Picaud SS]]
-
[[Category: Picaud, S S]]
+
[[Category: Pike ACW]]
-
[[Category: Pike, A C.W]]
+
[[Category: Pilka ES]]
-
[[Category: Pilka, E S]]
+
[[Category: Wikstrom M]]
-
[[Category: Wikstrom, M]]
+
[[Category: Yue WW]]
-
[[Category: Yue, W W]]
+
[[Category: Von Delft F]]
-
[[Category: Lyase]]
+
-
[[Category: Metal-binding]]
+

Current revision

Crystal structure of the human carbonic anhydrase related protein VIII

PDB ID 2w2j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w2j"
Personal tools