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2w3n

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==STRUCTURE AND INHIBITION OF THE CO2-SENSING CARBONIC ANHYDRASE CAN2 FROM THE PATHOGENIC FUNGUS CRYPTOCOCCUS NEOFORMANS==
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<StructureSection load='2w3n' size='340' side='right' caption='[[2w3n]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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==Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans==
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<StructureSection load='2w3n' size='340' side='right'caption='[[2w3n]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w3n]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_32045 Atcc 32045]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2w3n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans Cryptococcus neoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3n OCA], [http://pdbe.org/2w3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3n RCSB], [http://www.ebi.ac.uk/pdbsum/2w3n PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3n OCA], [https://pdbe.org/2w3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3n RCSB], [https://www.ebi.ac.uk/pdbsum/2w3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3n ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q3I4V7_CRYNV Q3I4V7_CRYNV]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3n_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3n_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Carbonic anhydrase|Carbonic anhydrase]]
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 32045]]
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[[Category: Cryptococcus neoformans]]
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[[Category: Carbonate dehydratase]]
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[[Category: Large Structures]]
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[[Category: Gertz, M]]
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[[Category: Gertz M]]
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[[Category: Hall, R A]]
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[[Category: Hall RA]]
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[[Category: Middelhaufe, S]]
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[[Category: Middelhaufe S]]
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[[Category: Muehlschlegel, F A]]
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[[Category: Muehlschlegel FA]]
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[[Category: Schlicker, C]]
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[[Category: Schlicker C]]
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[[Category: Steegborn, C]]
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[[Category: Steegborn C]]
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[[Category: Supuran, C T]]
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[[Category: Supuran CT]]
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[[Category: Vullo, D]]
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[[Category: Vullo D]]
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[[Category: Beta-class carbonic anhydrase]]
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[[Category: Cryptococcus neoforman]]
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[[Category: Inhibition]]
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[[Category: Lyase]]
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[[Category: Sulfonamide]]
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Current revision

Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans

PDB ID 2w3n

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