2w7w

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[[Image:2w7w.png|left|200px]]
 
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==The crystal structure of iron superoxide dismutase from Aliivibrio salmonicida.==
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The line below this paragraph, containing "STRUCTURE_2w7w", creates the "Structure Box" on the page.
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<StructureSection load='2w7w' size='340' side='right'caption='[[2w7w]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w7w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aliivibrio_salmonicida_LFI1238 Aliivibrio salmonicida LFI1238]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W7W FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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{{STRUCTURE_2w7w| PDB=2w7w | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7w OCA], [https://pdbe.org/2w7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w7w RCSB], [https://www.ebi.ac.uk/pdbsum/2w7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B6ENP9_ALISL B6ENP9_ALISL] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w7w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w7w ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Superoxide dismutases (SODs) are metalloenzymes that catalyse the dismutation of the superoxide radical anion into O(2) and H(2)O(2) in a two-step reaction. The crystal structure of the iron superoxide dismutase from the cold-adapted and fish-pathogenic bacterium Aliivibrio salmonicida (asFeSOD) has been determined and refined to 1.7 A resolution. The protein has been characterized and compared with the closely related homologous iron superoxide dismutase from the mesophilic Escherichia coli (ecFeSOD) in an attempt to rationalize its environmental adaptation. ecFeSOD shares 75% identity with asFeSOD. Compared with the mesophilic FeSOD, the psychrophilic FeSOD has distinct temperature differences in residual activity and thermostability that do not seem to be related to structural differences such as intramolecular or intermolecular ion bonds, hydrogen bonds or cavity sizes. However, an increased net negative charge on the surface of asFeSOD may explain its lower thermostability compared with ecFeSOD. Activity measurements and differential scanning calorimetry measurements revealed that the psychrophilic asFeSOD had a thermostability that was significantly higher than the optimal growth temperature of the host organism.
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===THE CRYSTAL STRUCTURE OF IRON SUPEROXIDE DISMUTASE FROM ALIIVIBRIO SALMONICIDA.===
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The first structure of a cold-adapted superoxide dismutase (SOD): biochemical and structural characterization of iron SOD from Aliivibrio salmonicida.,Pedersen HL, Willassen NP, Leiros I Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt, 2):84-92. Epub 2009 Jan 31. PMID:19193992<ref>PMID:19193992</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19193992}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2w7w" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19193992 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19193992}}
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==About this Structure==
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[[2w7w]] is a 2 chain structure of [[Superoxide Dismutase]] with sequence from [http://en.wikipedia.org/wiki/Aliivibrio_salmonicida Aliivibrio salmonicida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7W OCA].
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==See Also==
==See Also==
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*[[Superoxide Dismutase]]
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19193992</ref><references group="xtra"/>
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__TOC__
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[[Category: Aliivibrio salmonicida]]
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</StructureSection>
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[[Category: Superoxide dismutase]]
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[[Category: Aliivibrio salmonicida LFI1238]]
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[[Category: Leiros, I.]]
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[[Category: Large Structures]]
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[[Category: Pedersen, H L.]]
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[[Category: Leiros I]]
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[[Category: Willassen, N P.]]
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[[Category: Pedersen HL]]
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[[Category: Aliivibrio salmonicida]]
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[[Category: Willassen NP]]
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[[Category: Cold adaptation]]
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[[Category: Differential scanning calorimetry]]
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[[Category: Dsc]]
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[[Category: Fesod]]
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[[Category: Oxidoreductase]]
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[[Category: Sodb]]
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[[Category: Structural analysis]]
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[[Category: Superoxide dismutase]]
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Current revision

The crystal structure of iron superoxide dismutase from Aliivibrio salmonicida.

PDB ID 2w7w

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OCA

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