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2wfl

From Proteopedia

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Current revision (15:54, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2wfl' size='340' side='right'caption='[[2wfl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2wfl' size='340' side='right'caption='[[2wfl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wfl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wfl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wfm|2wfm]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfl OCA], [https://pdbe.org/2wfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfl RCSB], [https://www.ebi.ac.uk/pdbsum/2wfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfl OCA], [https://pdbe.org/2wfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfl RCSB], [https://www.ebi.ac.uk/pdbsum/2wfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE]] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>
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[https://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ophioxylon serpentinum]]
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[[Category: Rauvolfia serpentina]]
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[[Category: Polyneuridine-aldehyde esterase]]
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[[Category: Hill M]]
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[[Category: Hill, M]]
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[[Category: Panjikar S]]
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[[Category: Panjikar, S]]
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[[Category: Stoeckigt J]]
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[[Category: Stoeckigt, J]]
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[[Category: Wang M]]
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[[Category: Wang, M]]
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[[Category: Yang L]]
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[[Category: Yang, L]]
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[[Category: Alkaloid metabolism]]
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[[Category: Hydrolase]]
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[[Category: Monoterpenoid indole alkaloid]]
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[[Category: Pnae]]
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[[Category: Serine esterase]]
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Current revision

Crystal structure of polyneuridine aldehyde esterase

PDB ID 2wfl

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