8hkp

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(New page: '''Unreleased structure''' The entry 8hkp is ON HOLD Authors: Lee, S.N., Cho, H.J., Jeong, H., Ryu, B., Lee, H.J., Lee, H.H., Woo, J.S. Description: Conformationally hetero-junctional ...)
Current revision (16:13, 13 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8hkp is ON HOLD
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==Structurally hetero-junctional human Cx36/GJD2 gap junction channel in detergents (C6 symmetry)==
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<StructureSection load='8hkp' size='340' side='right'caption='[[8hkp]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8hkp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HKP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AV0:2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl+4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside'>AV0</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hkp OCA], [https://pdbe.org/8hkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hkp RCSB], [https://www.ebi.ac.uk/pdbsum/8hkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hkp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CXD2_HUMAN CXD2_HUMAN] One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Connexin 36 (Cx36) is responsible for signal transmission in electrical synapses by forming interneuronal gap junctions. Despite the critical role of Cx36 in normal brain function, the molecular architecture of the Cx36 gap junction channel (GJC) is unknown. Here, we determine cryo-electron microscopy structures of Cx36 GJC at 2.2-3.6 A resolutions, revealing a dynamic equilibrium between its closed and open states. In the closed state, channel pores are obstructed by lipids, while N-terminal helices (NTHs) are excluded from the pore. In the open state with pore-lining NTHs, the pore is more acidic than those in Cx26 and Cx46/50 GJCs, explaining its strong cation selectivity. The conformational change during channel opening also includes the alpha-to-pi-helix transition of the first transmembrane helix, which weakens the protomer-protomer interaction. Our structural analyses provide high resolution information on the conformational flexibility of Cx36 GJC and suggest a potential role of lipids in the channel gating.
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Authors: Lee, S.N., Cho, H.J., Jeong, H., Ryu, B., Lee, H.J., Lee, H.H., Woo, J.S.
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Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel.,Lee SN, Cho HJ, Jeong H, Ryu B, Lee HJ, Kim M, Yoo J, Woo JS, Lee HH Nat Commun. 2023 Mar 11;14(1):1347. doi: 10.1038/s41467-023-37040-8. PMID:36906653<ref>PMID:36906653</ref>
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Description: Conformationally hetero-junctional human Cx36/GJD2 gap junction channel in detergents (C6 symmetry)
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Woo, J.S]]
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<div class="pdbe-citations 8hkp" style="background-color:#fffaf0;"></div>
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[[Category: Lee, H.H]]
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== References ==
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[[Category: Jeong, H]]
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<references/>
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[[Category: Lee, H.J]]
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__TOC__
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[[Category: Lee, S.N]]
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</StructureSection>
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[[Category: Cho, H.J]]
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[[Category: Homo sapiens]]
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[[Category: Ryu, B]]
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[[Category: Large Structures]]
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[[Category: Cho HJ]]
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[[Category: Jeong H]]
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[[Category: Lee HH]]
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[[Category: Lee HJ]]
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[[Category: Lee SN]]
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[[Category: Ryu B]]
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[[Category: Woo JS]]

Current revision

Structurally hetero-junctional human Cx36/GJD2 gap junction channel in detergents (C6 symmetry)

PDB ID 8hkp

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