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2a2v

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[[Image:2a2v.gif|left|200px]]
 
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==The solution structure of Jingzhaotoxin-XI==
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The line below this paragraph, containing "STRUCTURE_2a2v", creates the "Structure Box" on the page.
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<StructureSection load='2a2v' size='340' side='right'caption='[[2a2v]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2a2v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chilobrachys_guangxiensis Chilobrachys guangxiensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2v OCA], [https://pdbe.org/2a2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2v RCSB], [https://www.ebi.ac.uk/pdbsum/2a2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2v ProSAT]</span></td></tr>
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{{STRUCTURE_2a2v| PDB=2a2v | SCENE= }}
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</table>
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== Function ==
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'''The solution structure of Jingzhaotoxin-XI'''
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[https://www.uniprot.org/uniprot/JZ11A_CHIGU JZ11A_CHIGU] Inhibits voltage-gated potassium channels (Kv2.1/KCNB1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel. Shows no significant toxic symptoms when injected into mice and into cockroaches.<ref>PMID:17176080</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2V OCA].
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</StructureSection>
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[[Category: Liang, S P.]]
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[[Category: Chilobrachys guangxiensis]]
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[[Category: Liao, Z.]]
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[[Category: Large Structures]]
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[[Category: Ick motif]]
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[[Category: Liang SP]]
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[[Category: Neurotoxin spider]]
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[[Category: Liao Z]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:32:03 2008''
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Current revision

The solution structure of Jingzhaotoxin-XI

PDB ID 2a2v

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