2ezd

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[[Image:2ezd.png|left|200px]]
 
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==SOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_2ezd", creates the "Structure Box" on the page.
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<StructureSection load='2ezd' size='340' side='right'caption='[[2ezd]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ezd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EZD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ezd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ezd OCA], [https://pdbe.org/2ezd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ezd RCSB], [https://www.ebi.ac.uk/pdbsum/2ezd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ezd ProSAT]</span></td></tr>
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{{STRUCTURE_2ezd| PDB=2ezd | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HMGA1_HUMAN HMGA1_HUMAN] A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.
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== Function ==
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[https://www.uniprot.org/uniprot/HMGA1_HUMAN HMGA1_HUMAN] HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of a complex between a truncated form of HMG-I(Y), consisting of the second and third DNA binding domains (residues 51-90), and a DNA dodecamer containing the PRDII site of the interferon-beta promoter has been solved by multidimensional nuclear magnetic resonance spectroscopy. The stoichiometry of the complex is one molecule of HMG-I(Y) to two molecules of DNA. The structure reveals a new architectural minor groove binding motif which stabilizes B-DNA, thereby facilitating the binding of other transcription factors in the opposing major groove. The interactions involve a central Arg-Gly-Arg motif together with two other modules that participate in extensive hydrophobic and polar contracts. The absence of one of these modules in the third DNA binding domain accounts for its-100 fold reduced affinity relative to the second one.
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===SOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, MINIMIZED AVERAGE STRUCTURE===
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The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.,Huth JR, Bewley CA, Nissen MS, Evans JN, Reeves R, Gronenborn AM, Clore GM Nat Struct Biol. 1997 Aug;4(8):657-65. PMID:9253416<ref>PMID:9253416</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ezd" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9253416}}, adds the Publication Abstract to the page
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*[[HMGI(Y)|HMGI(Y)]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9253416 is the PubMed ID number.
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*[[High mobility group protein|High mobility group protein]]
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== References ==
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{{ABSTRACT_PUBMED_9253416}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2EZD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EZD OCA].
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==Reference==
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The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif., Huth JR, Bewley CA, Nissen MS, Evans JN, Reeves R, Gronenborn AM, Clore GM, Nat Struct Biol. 1997 Aug;4(8):657-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9253416 9253416]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bewley, C.]]
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[[Category: Bewley C]]
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[[Category: Clore, G M.]]
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[[Category: Clore GM]]
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[[Category: Gronenborn, A M.]]
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[[Category: Gronenborn AM]]
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[[Category: Huth, J R.]]
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[[Category: Huth JR]]
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[[Category: Architectural factor]]
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[[Category: Dna binding protein]]
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[[Category: Minor groove dna binding]]
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[[Category: Transcriptional co-activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:37:19 2008''
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Current revision

SOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 2ezd

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