This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5ojm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:52, 13 December 2023) (edit) (undo)
 
Line 1: Line 1:
==Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25==
==Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25==
-
<StructureSection load='5ojm' size='340' side='right' caption='[[5ojm]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
+
<StructureSection load='5ojm' size='340' side='right'caption='[[5ojm]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5ojm]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OJM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5ojm]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OJM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABRA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ojm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojm OCA], [http://pdbe.org/5ojm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ojm RCSB], [http://www.ebi.ac.uk/pdbsum/5ojm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojm ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ojm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojm OCA], [https://pdbe.org/5ojm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ojm RCSB], [https://www.ebi.ac.uk/pdbsum/5ojm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojm ProSAT]</span></td></tr>
</table>
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.[https://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Camelus glama]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Lama glama]]
-
[[Category: Aricescu, A R]]
+
[[Category: Large Structures]]
-
[[Category: Colibus, L De]]
+
[[Category: Synthetic construct]]
-
[[Category: Masiulis, S]]
+
[[Category: Aricescu AR]]
-
[[Category: Miller, P S]]
+
[[Category: De Colibus L]]
-
[[Category: Pardon, E]]
+
[[Category: Masiulis S]]
-
[[Category: Scott, S]]
+
[[Category: Miller PS]]
-
[[Category: Steyaert, J]]
+
[[Category: Pardon E]]
-
[[Category: Gabaa receptor]]
+
[[Category: Scott S]]
-
[[Category: Ion channel]]
+
[[Category: Steyaert J]]
-
[[Category: Membrane protein]]
+
-
[[Category: Nanobody complex]]
+
-
[[Category: Neurosteroid]]
+

Current revision

Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25

PDB ID 5ojm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ojm"
Personal tools