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5opo

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==Crystal structure of R238G cN-II mutant==
==Crystal structure of R238G cN-II mutant==
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<StructureSection load='5opo' size='340' side='right' caption='[[5opo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5opo' size='340' side='right'caption='[[5opo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5opo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OPO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5opo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OPO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5opl|5opl]], [[5opk|5opk]], [[5opm|5opm]], [[5opn|5opn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5opo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5opo OCA], [https://pdbe.org/5opo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5opo RCSB], [https://www.ebi.ac.uk/pdbsum/5opo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5opo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5opo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5opo OCA], [http://pdbe.org/5opo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5opo RCSB], [http://www.ebi.ac.uk/pdbsum/5opo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5opo ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref>
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[https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
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[https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5'-nucleotidase]]
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[[Category: Homo sapiens]]
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[[Category: Hnizda, A]]
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[[Category: Large Structures]]
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[[Category: Pachl, P]]
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[[Category: Hnizda A]]
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[[Category: Rezacova, P]]
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[[Category: Pachl P]]
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[[Category: Hydrolase]]
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[[Category: Rezacova P]]
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[[Category: Nucleotidase]]
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[[Category: Relapsed leukemia]]
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Current revision

Crystal structure of R238G cN-II mutant

PDB ID 5opo

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