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8fh6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8fh6 is ON HOLD Authors: Arenas, R., Wilson, D.K. Description: Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001 [...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001== | |
| - | + | <StructureSection load='8fh6' size='340' side='right'caption='[[8fh6]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8fh6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FH6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.952Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=XXQ:(8-oxo-7-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetic+acid'>XXQ</scene></td></tr> |
| - | [[Category: Arenas | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fh6 OCA], [https://pdbe.org/8fh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fh6 RCSB], [https://www.ebi.ac.uk/pdbsum/8fh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fh6 ProSAT]</span></td></tr> |
| - | [[Category: Wilson | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arenas R]] | ||
| + | [[Category: Wilson DK]] | ||
Current revision
Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001
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