8hoc

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'''Unreleased structure'''
 
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The entry 8hoc is ON HOLD until Paper Publication
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==Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex==
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<StructureSection load='8hoc' size='340' side='right'caption='[[8hoc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8hoc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HOC FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ITF:2-(1~{H}-imidazol-5-yl)ethyl+carbamimidothioate'>ITF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hoc OCA], [https://pdbe.org/8hoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hoc RCSB], [https://www.ebi.ac.uk/pdbsum/8hoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hoc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li FH]]
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[[Category: Sun XY]]
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[[Category: Tang WQ]]
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[[Category: Wang JY]]

Revision as of 10:01, 20 December 2023

Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex

PDB ID 8hoc

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