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8teq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber== | |
| - | + | <StructureSection load='8teq' size='340' side='right'caption='[[8teq]], [[Resolution|resolution]] 2.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8teq]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Purpureocillium_lilacinum Purpureocillium lilacinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TEQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.84Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8teq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8teq OCA], [https://pdbe.org/8teq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8teq RCSB], [https://www.ebi.ac.uk/pdbsum/8teq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8teq ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: Eisenberg | + | [https://www.uniprot.org/uniprot/TFG_HUMAN TFG_HUMAN] Autosomal recessive spastic paraplegia type 57;Extraskeletal myxoid chondrosarcoma;Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation;Hereditary motor and sensory neuropathy, Okinawa type;Differentiated thyroid carcinoma. A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.<ref>PMID:7565764</ref> The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. |
| - | [[Category: Ge | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TFG_HUMAN TFG_HUMAN] Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).<ref>PMID:21478858</ref> <ref>PMID:23479643</ref> <ref>PMID:27813252</ref> [https://www.uniprot.org/uniprot/A0A2U3DNX3_PURLI A0A2U3DNX3_PURLI] |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Purpureocillium lilacinum]] | ||
| + | [[Category: Abskharon R]] | ||
| + | [[Category: Boyer DR]] | ||
| + | [[Category: Eisenberg DS]] | ||
| + | [[Category: Ge P]] | ||
| + | [[Category: Rosenberg GM]] | ||
| + | [[Category: Sawaya MR]] | ||
Current revision
Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber
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