This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8ter
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber== | |
| - | + | <StructureSection load='8ter' size='340' side='right'caption='[[8ter]], [[Resolution|resolution]] 2.59Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ter]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Purpureocillium_lilacinum Purpureocillium lilacinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TER FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.59Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ter FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ter OCA], [https://pdbe.org/8ter PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ter RCSB], [https://www.ebi.ac.uk/pdbsum/8ter PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ter ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: Eisenberg | + | [https://www.uniprot.org/uniprot/TFG_HUMAN TFG_HUMAN] Autosomal recessive spastic paraplegia type 57;Extraskeletal myxoid chondrosarcoma;Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation;Hereditary motor and sensory neuropathy, Okinawa type;Differentiated thyroid carcinoma. A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.<ref>PMID:7565764</ref> The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. |
| - | [[Category: Ge | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TFG_HUMAN TFG_HUMAN] Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).<ref>PMID:21478858</ref> <ref>PMID:23479643</ref> <ref>PMID:27813252</ref> [https://www.uniprot.org/uniprot/A0A2U3DNX3_PURLI A0A2U3DNX3_PURLI] |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Purpureocillium lilacinum]] | ||
| + | [[Category: Abskharon R]] | ||
| + | [[Category: Boyer DR]] | ||
| + | [[Category: Eisenberg DS]] | ||
| + | [[Category: Ge P]] | ||
| + | [[Category: Rosenberg GM]] | ||
| + | [[Category: Sawaya MR]] | ||
Current revision
Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber
| |||||||||||
