This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jnz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:08, 20 December 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2jnz.png|left|200px]]
 
-
<!--
+
==Solution structure of phl p 3, a major allergen from timothy grass pollen==
-
The line below this paragraph, containing "STRUCTURE_2jnz", creates the "Structure Box" on the page.
+
<StructureSection load='2jnz' size='340' side='right'caption='[[2jnz]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2jnz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JNZ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnz OCA], [https://pdbe.org/2jnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jnz RCSB], [https://www.ebi.ac.uk/pdbsum/2jnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jnz ProSAT]</span></td></tr>
-
{{STRUCTURE_2jnz| PDB=2jnz | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q69B42_PHLPR Q69B42_PHLPR]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/2jnz_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jnz ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The major 97-aa timothy grass (Phleum pratense) allergen Phl p 3 was recently isolated from an extract of timothy grass pollen. Sequence comparison classifies this protein as a group 3 allergen. The solution structure of Phl p 3 as determined by nuclear magnetic resonance spectroscopy reveals that the protein consists of a core of hydrophobic amino-acid side chains from two beta-sheets of five and four anti-parallel beta-strands, respectively. This conformation is very similar to the crystal structure published for Phl p 2 and strongly resembles the known conformation of the carboxy-terminal domain of Phl p 1, the major difference being the loop orientations. Phl p 2 and Phl p 3 show virtually identical immunoreactivity, and comparison of the charged surface amino acids of the two proteins gives initial clues as to the IgE recognition epitopes of these proteins.
-
===Solution structure of phl p 3, a major allergen from timothy grass pollen===
+
Solution structure of Phl p 3, a major allergen from timothy grass pollen.,Schweimer K, Petersen A, Suck R, Becker WM, Rosch P, Matecko I Biol Chem. 2008 Jul;389(7):919-23. PMID:18627309<ref>PMID:18627309</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18627309}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2jnz" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18627309 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18627309}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2JNZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNZ OCA].
+
-
 
+
-
==Reference==
+
-
Solution structure of Phl p 3, a major allergen from timothy grass pollen., Schweimer K, Petersen A, Suck R, Becker WM, Rosch P, Matecko I, Biol Chem. 2008 Jul;389(7):919-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18627309 18627309]
+
[[Category: Phleum pratense]]
[[Category: Phleum pratense]]
-
[[Category: Single protein]]
+
[[Category: Matecko I]]
-
[[Category: Matecko, I.]]
+
[[Category: Roesch P]]
-
[[Category: Roesch, P.]]
+
[[Category: Schweimer K]]
-
[[Category: Schweimer, K.]]
+
-
[[Category: Allergen]]
+
-
[[Category: Timothy grass pollen]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 20 11:31:07 2008''
+

Current revision

Solution structure of phl p 3, a major allergen from timothy grass pollen

PDB ID 2jnz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jnz"
Personal tools