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2jr7

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[[Image:2jr7.jpg|left|200px]]
 
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{{Structure
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==Solution structure of human DESR1==
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|PDB= 2jr7 |SIZE=350|CAPTION= <scene name='initialview01'>2jr7</scene>
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<StructureSection load='2jr7' size='340' side='right'caption='[[2jr7]]' scene=''>
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+90'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2jr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JR7 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= DPH3, DESR1, ZCSL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5216 COG5216]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jr7 OCA], [https://pdbe.org/2jr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jr7 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jr7 OCA], [http://www.ebi.ac.uk/pdbsum/2jr7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jr7 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DPH3_HUMAN DPH3_HUMAN] Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity).<ref>PMID:14980502</ref> <ref>PMID:14527407</ref> Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.<ref>PMID:14980502</ref> <ref>PMID:14527407</ref>
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== Evolutionary Conservation ==
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'''Solution structure of human DESR1'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jr7_consurf.spt"</scriptWhenChecked>
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2JR7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR7 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Solution structure of human DESR1, a CSL zinc-binding protein., Wu F, Zhang J, Sun J, Huang H, Ji P, Chu W, Yu M, Yang F, Wu Z, Wu J, Shi Y, Proteins. 2008 Apr;71(1):514-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18214955 18214955]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jr7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Shi, Y.]]
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[[Category: Shi Y]]
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[[Category: Wu, F.]]
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[[Category: Wu F]]
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[[Category: Wu, J.]]
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[[Category: Wu J]]
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[[Category: csl zinc finger]]
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[[Category: desr1]]
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[[Category: metal binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:00:57 2008''
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Current revision

Solution structure of human DESR1

PDB ID 2jr7

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