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2jsc

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==NMR structure of the cadmium metal-sensor CMTR from Mycobacterium tuberculosis==
==NMR structure of the cadmium metal-sensor CMTR from Mycobacterium tuberculosis==
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<StructureSection load='2jsc' size='340' side='right' caption='[[2jsc]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
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<StructureSection load='2jsc' size='340' side='right'caption='[[2jsc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jsc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jsc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv1994c, MT2050, MTCY39.25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsc RCSB], [http://www.ebi.ac.uk/pdbsum/2jsc PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsc OCA], [https://pdbe.org/2jsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsc RCSB], [https://www.ebi.ac.uk/pdbsum/2jsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CMTR_MYCTU CMTR_MYCTU] Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.<ref>PMID:12939264</ref> <ref>PMID:15966722</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsc_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsc_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jsc ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2jsc" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mycobacterium tuberculosis h37rv]]
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[[Category: Large Structures]]
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[[Category: Banci, L]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Bertini, I]]
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[[Category: Banci L]]
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[[Category: Cantini, F]]
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[[Category: Bertini I]]
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[[Category: Cavet, J S]]
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[[Category: Cantini F]]
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[[Category: Ciofi-Baffoni, S]]
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[[Category: Cavet JS]]
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[[Category: Dennison, C]]
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[[Category: Ciofi-Baffoni S]]
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[[Category: Graham, A I]]
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[[Category: Dennison C]]
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[[Category: Harvie, D R]]
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[[Category: Graham AI]]
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[[Category: Robinson, N J]]
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[[Category: Harvie DR]]
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[[Category: SPINE, Structural Proteomics in Europe]]
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[[Category: Robinson NJ]]
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[[Category: Cadmium]]
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[[Category: Solution structure]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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[[Category: Transcription]]
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[[Category: Transcriptional repressor]]
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Current revision

NMR structure of the cadmium metal-sensor CMTR from Mycobacterium tuberculosis

PDB ID 2jsc

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