This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2wok

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:12, 20 December 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
==CLAVULANIC ACID BIOSYNTHESIS OLIGOPEPTIDE BINDING PROTEIN 2 COMPLEXED WITH BRADYKININ==
+
==Clavulanic acid biosynthesis oligopeptide binding protein 2 complexed with bradykinin==
-
<StructureSection load='2wok' size='340' side='right' caption='[[2wok]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+
<StructureSection load='2wok' size='340' side='right'caption='[[2wok]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2wok]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOK FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2wok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOK FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wol|2wol]], [[2wop|2wop]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wok OCA], [http://pdbe.org/2wok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wok RCSB], [http://www.ebi.ac.uk/pdbsum/2wok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wok ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wok OCA], [https://pdbe.org/2wok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wok RCSB], [https://www.ebi.ac.uk/pdbsum/2wok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wok ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/KNG1_HUMAN KNG1_HUMAN]] Congenital high-molecular-weight kininogen deficiency. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/KNG1_HUMAN KNG1_HUMAN]] (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
+
[https://www.uniprot.org/uniprot/Q8KRB4_STRCL Q8KRB4_STRCL]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wok_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wok_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 33: Line 31:
==See Also==
==See Also==
-
*[[Oligopeptide-binding protein|Oligopeptide-binding protein]]
+
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Andersson, I]]
+
[[Category: Homo sapiens]]
-
[[Category: Caines, M E.C]]
+
[[Category: Large Structures]]
-
[[Category: Iqbal, A]]
+
[[Category: Streptomyces clavuligerus]]
-
[[Category: Jensen, S E]]
+
[[Category: Andersson I]]
-
[[Category: Kershaw, N J]]
+
[[Category: Caines MEC]]
-
[[Category: Mackenzie, A K]]
+
[[Category: Iqbal A]]
-
[[Category: Schofield, C J]]
+
[[Category: Jensen SE]]
-
[[Category: Valegard, K]]
+
[[Category: Kershaw NJ]]
-
[[Category: Bradykinin]]
+
[[Category: Mackenzie AK]]
-
[[Category: Clavulanic acid biosynthesis]]
+
[[Category: Schofield CJ]]
-
[[Category: Oligopeptide]]
+
[[Category: Valegard K]]
-
[[Category: Oligopeptide binding protein]]
+
-
[[Category: Peptide binding protein-peptide complex]]
+
-
[[Category: Solute-binding protein]]
+

Current revision

Clavulanic acid biosynthesis oligopeptide binding protein 2 complexed with bradykinin

PDB ID 2wok

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wok"
Personal tools