2wp7

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[[Image:2wp7.png|left|200px]]
 
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==Crystal structure of deSUMOylase(DUF862)==
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The line below this paragraph, containing "STRUCTURE_2wp7", creates the "Structure Box" on the page.
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<StructureSection load='2wp7' size='340' side='right'caption='[[2wp7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wp7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WP7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wp7 OCA], [https://pdbe.org/2wp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wp7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wp7 ProSAT]</span></td></tr>
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{{STRUCTURE_2wp7| PDB=2wp7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DESI1_MOUSE DESI1_MOUSE] Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46.<ref>PMID:22370726</ref> <ref>PMID:22498933</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/2wp7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wp7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Post-translational modification by SUMO can be reversed by SENPs, the first known class of deSUMOylase. Recently, we identified a new deSUMOylating enzyme DeSI-1, which is distinct from SENPs and belongs to the putative deubiquitinating isopeptidase PPPDE superfamily. Herein, we report the crystal structure of DeSI-1, revealing that this enzyme forms a homodimer and that the groove between the two subunits is the active site harboring two absolutely conserved cysteine and histidine residues which form a catalytic dyad. We also show that DeSI-1 exhibits an extremely low endopeptidase activity toward precursor forms of SUMO-1 and SUMO-2, unlike SENPs. Proteins 2012. (c) 2012 Wiley-Liss, Inc.
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===Crystal structure of deSUMOylase(DUF862)===
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Crystal structure of DeSI-1, a novel deSUMOylase belonging to a putative isopeptidase superfamily.,Suh HY, Kim JH, Woo JS, Ku B, Shin EJ, Yun Y, Oh BH Proteins. 2012 Apr 13. doi: 10.1002/prot.24093. PMID:22498933<ref>PMID:22498933</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22498933}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wp7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22498933 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22498933}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2wp7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WP7 OCA].
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==Reference==
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<ref group="xtra">PMID:022498933</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Kim, J H.]]
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[[Category: Kim JH]]
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[[Category: Oh, B H.]]
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[[Category: Oh BH]]
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[[Category: Woo, J S.]]
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[[Category: Woo JS]]
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[[Category: Hydrolase]]
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[[Category: Phosphoprotein]]
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[[Category: Ubiquitin-like protein]]
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Current revision

Crystal structure of deSUMOylase(DUF862)

PDB ID 2wp7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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