2wqr

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[[Image:2wqr.png|left|200px]]
 
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==The high resolution crystal structure of IgE Fc==
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The line below this paragraph, containing "STRUCTURE_2wqr", creates the "Structure Box" on the page.
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<StructureSection load='2wqr' size='340' side='right'caption='[[2wqr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wqr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_2wqr| PDB=2wqr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqr OCA], [https://pdbe.org/2wqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqr RCSB], [https://www.ebi.ac.uk/pdbsum/2wqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IGHE_HUMAN IGHE_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Among antibody classes, IgE has a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor FcvarepsilonRI. We show the structural basis for these key determinants of the ability of IgE to mediate allergic hypersensitivity through the 3.4-A-resolution crystal structure of human IgE-Fc (consisting of the Cvarepsilon2, Cvarepsilon3 and Cvarepsilon4 domains) bound to the extracellular domains of the FcvarepsilonRI alpha chain. Comparison with the structure of free IgE-Fc (reported here at a resolution of 1.9 A) shows that the antibody, which has a compact, bent structure before receptor engagement, becomes even more acutely bent in the complex. Thermodynamic analysis indicates that the interaction is entropically driven, which explains how the noncontacting Cvarepsilon2 domains, in place of the flexible hinge region of IgG antibodies, contribute together with the conformational changes to the unique binding properties of IgE.
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===THE HIGH RESOLUTION CRYSTAL STRUCTURE OF IGE FC===
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Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcvarepsilonRI.,Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ Nat Struct Mol Biol. 2011 May;18(5):571-6. Epub 2011 Apr 24. PMID:21516097<ref>PMID:21516097</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12068291}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wqr" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12068291 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12068291}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2wqr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQR OCA].
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==Reference==
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<ref group="xtra">PMID:12068291</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Beavil, A J.]]
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[[Category: Large Structures]]
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[[Category: Dhaliwal, B.]]
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[[Category: Beavil AJ]]
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[[Category: Sutton, B J.]]
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[[Category: Dhaliwal B]]
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[[Category: Sutton BJ]]

Current revision

The high resolution crystal structure of IgE Fc

PDB ID 2wqr

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OCA

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