2wqz

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[[Image:2wqz.png|left|200px]]
 
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==Crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement==
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The line below this paragraph, containing "STRUCTURE_2wqz", creates the "Structure Box" on the page.
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<StructureSection load='2wqz' size='340' side='right'caption='[[2wqz]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wqz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vh8 2vh8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_2wqz| PDB=2wqz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqz OCA], [https://pdbe.org/2wqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqz RCSB], [https://www.ebi.ac.uk/pdbsum/2wqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqz ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NLGNX_HUMAN NLGNX_HUMAN] Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2) [MIM:[https://omim.org/entry/300495 300495]. AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.<ref>PMID:12669065</ref> Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2) [MIM:[https://omim.org/entry/300497 300497]. ASPGX2 is considered to be a form of childhood autism.
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== Function ==
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[https://www.uniprot.org/uniprot/NLGNX_HUMAN NLGNX_HUMAN] Putative neuronal cell surface protein involved in cell-cell-interactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wqz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wqz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The neuroligins are postsynaptic cell adhesion proteins whose associations with presynaptic neurexins participate in synaptogenesis. Mutations in the neuroligin and neurexin genes appear to be associated with autism and mental retardation. The crystal structure of a neuroligin reveals features not found in its catalytically active relatives, such as the fully hydrophobic interface forming the functional neuroligin dimer; the conformations of surface loops surrounding the vestigial active center; the location of determinants that are critical for folding and processing; and the absence of a macromolecular dipole and presence of an electronegative, hydrophilic surface for neurexin binding. The structure of a beta-neurexin-neuroligin complex reveals the precise orientation of the bound neurexin and, despite a limited resolution, provides substantial information on the Ca2+-dependent interactions network involved in trans-synaptic neurexin-neuroligin association. These structures exemplify how an alpha/beta-hydrolase fold varies in surface topography to confer adhesion properties and provide templates for analyzing abnormal processing or recognition events associated with autism.
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===CRYSTAL STRUCTURE OF SYNAPTIC PROTEIN NEUROLIGIN-4 IN COMPLEX WITH NEUREXIN-BETA 1: ALTERNATIVE REFINEMENT===
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Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.,Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P Neuron. 2007 Dec 20;56(6):979-91. PMID:18093521<ref>PMID:18093521</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2wqz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18093521 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18093521}}
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==About this Structure==
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[[2wqz]] is a 4 chain structure of [[Neurexin]] and [[Neuroligin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vh8 2vh8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQZ OCA].
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==See Also==
==See Also==
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*[[Neurexin]]
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*[[Neurexin|Neurexin]]
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*[[Neuroligin]]
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*[[Neuroligin|Neuroligin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18093521</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bourne, Y.]]
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[[Category: Bourne Y]]
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[[Category: Comoletti, D.]]
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[[Category: Comoletti D]]
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[[Category: Fabrichny, I P.]]
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[[Category: Fabrichny IP]]
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[[Category: Leone, P.]]
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[[Category: Leone P]]
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[[Category: Marchot, P.]]
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[[Category: Marchot P]]
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[[Category: Miller, M T.]]
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[[Category: Miller MT]]
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[[Category: Sulzenbacher, G.]]
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[[Category: Sulzenbacher G]]
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[[Category: Taylor, P.]]
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[[Category: Taylor P]]
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[[Category: Alpha/beta-hydrolase cholinesterase autism brain]]
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[[Category: Alternative promoter usage]]
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[[Category: Alternative splicing]]
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[[Category: Cell adhesion]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Polymorphism]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement

PDB ID 2wqz

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