This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2wqz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:14, 20 December 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
==CRYSTAL STRUCTURE OF SYNAPTIC PROTEIN NEUROLIGIN-4 IN COMPLEX WITH NEUREXIN-BETA 1: ALTERNATIVE REFINEMENT==
+
 
-
<StructureSection load='2wqz' size='340' side='right' caption='[[2wqz]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
+
==Crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement==
 +
<StructureSection load='2wqz' size='340' side='right'caption='[[2wqz]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2wqz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vh8 2vh8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQZ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2wqz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vh8 2vh8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQZ FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5AX:2-(ACETYLAMINO)-1,5-ANHYDRO-2-DEOXY-D-GLUCITOL'>5AX</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c4r|1c4r]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wqz RCSB], [http://www.ebi.ac.uk/pdbsum/2wqz PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqz OCA], [https://pdbe.org/2wqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqz RCSB], [https://www.ebi.ac.uk/pdbsum/2wqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqz ProSAT]</span></td></tr>
-
<table>
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/NLGNX_HUMAN NLGNX_HUMAN] Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2) [MIM:[https://omim.org/entry/300495 300495]. AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.<ref>PMID:12669065</ref> Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2) [MIM:[https://omim.org/entry/300497 300497]. ASPGX2 is considered to be a form of childhood autism.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NLGNX_HUMAN NLGNX_HUMAN] Putative neuronal cell surface protein involved in cell-cell-interactions.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wqz_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wqz_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wqz ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 25: Line 30:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2wqz" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Neurexin|Neurexin]]
*[[Neurexin|Neurexin]]
*[[Neuroligin|Neuroligin]]
*[[Neuroligin|Neuroligin]]
-
*[[Neuroligin-Neurexin Interaction|Neuroligin-Neurexin Interaction]]
 
== References ==
== References ==
<references/>
<references/>
Line 35: Line 40:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Bourne, Y.]]
+
[[Category: Bourne Y]]
-
[[Category: Comoletti, D.]]
+
[[Category: Comoletti D]]
-
[[Category: Fabrichny, I P.]]
+
[[Category: Fabrichny IP]]
-
[[Category: Leone, P.]]
+
[[Category: Leone P]]
-
[[Category: Marchot, P.]]
+
[[Category: Marchot P]]
-
[[Category: Miller, M T.]]
+
[[Category: Miller MT]]
-
[[Category: Sulzenbacher, G.]]
+
[[Category: Sulzenbacher G]]
-
[[Category: Taylor, P.]]
+
[[Category: Taylor P]]
-
[[Category: Alpha/beta-hydrolase cholinesterase autism brain]]
+
-
[[Category: Alternative promoter usage]]
+
-
[[Category: Cell adhesion]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Membrane]]
+
-
[[Category: Transmembrane]]
+

Current revision

Crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement

PDB ID 2wqz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wqz"
Personal tools