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2wub

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==Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp==
==Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp==
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<StructureSection load='2wub' size='340' side='right' caption='[[2wub]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='2wub' size='340' side='right'caption='[[2wub]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wub]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WUB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wub]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WUB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ybw|1ybw]], [[1yc0|1yc0]], [[2wuc|2wuc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wub OCA], [http://pdbe.org/2wub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wub RCSB], [http://www.ebi.ac.uk/pdbsum/2wub PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wub OCA], [https://pdbe.org/2wub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wub RCSB], [https://www.ebi.ac.uk/pdbsum/2wub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wub ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN]] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
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[https://www.uniprot.org/uniprot/HGFA_HUMAN HGFA_HUMAN] Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/2wub_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/2wub_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
*[[Hepatocyte growth factor activator|Hepatocyte growth factor activator]]
*[[Hepatocyte growth factor activator|Hepatocyte growth factor activator]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Eigenbrot, C]]
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[[Category: Large Structures]]
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[[Category: Ganesan, R]]
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[[Category: Eigenbrot C]]
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[[Category: Shia, S]]
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[[Category: Ganesan R]]
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[[Category: Allosteric inhibitor]]
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[[Category: Shia S]]
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[[Category: Antibody]]
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[[Category: Disulfide bond]]
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[[Category: Egf-like domain]]
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[[Category: Fab complex]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase immune system complex]]
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[[Category: Hydrolase-immune system complex]]
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[[Category: Kringle]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]
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Current revision

Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp

PDB ID 2wub

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