This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2wz9
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Crystal structure of the thioredoxin domain of human TXNL2== | ==Crystal structure of the thioredoxin domain of human TXNL2== | ||
| - | <StructureSection load='2wz9' size='340' side='right' caption='[[2wz9]], [[Resolution|resolution]] 1.55Å' scene=''> | + | <StructureSection load='2wz9' size='340' side='right'caption='[[2wz9]], [[Resolution|resolution]] 1.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wz9]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZ9 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wz9 OCA], [https://pdbe.org/2wz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2wz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wz9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLRX3_HUMAN GLRX3_HUMAN] Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 18: | Line 21: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Cocking R]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Johannson | + | [[Category: Johannson C]] |
| - | [[Category: Kavanagh | + | [[Category: Kavanagh KL]] |
| - | [[Category: Muniz | + | [[Category: Muniz JRC]] |
| - | [[Category: Pike | + | [[Category: Pike ACW]] |
| - | [[Category: Vollmar | + | [[Category: Vollmar M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
Current revision
Crystal structure of the thioredoxin domain of human TXNL2
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Cocking R | Edwards A | Johannson C | Kavanagh KL | Muniz JRC | Pike ACW | Vollmar M | Weigelt J | Von Delft F
