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2x6i

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==THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-90==
==THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-90==
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<StructureSection load='2x6i' size='340' side='right' caption='[[2x6i]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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<StructureSection load='2x6i' size='340' side='right'caption='[[2x6i]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x6i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X6I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X6I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=090:N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C]+QUINAZOLIN-5-YL)NICOTINAMIDE'>090</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x6k|2x6k]], [[2x6h|2x6h]], [[2x6f|2x6f]], [[2x6j|2x6j]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=090:N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C]+QUINAZOLIN-5-YL)NICOTINAMIDE'>090</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x6i OCA], [http://pdbe.org/2x6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x6i RCSB], [http://www.ebi.ac.uk/pdbsum/2x6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x6i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x6i OCA], [https://pdbe.org/2x6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x6i RCSB], [https://www.ebi.ac.uk/pdbsum/2x6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x6i ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9W1M7_DROME Q9W1M7_DROME]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/2x6i_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/2x6i_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]]
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Houseman, B T]]
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[[Category: Large Structures]]
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[[Category: Miller, S]]
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[[Category: Houseman BT]]
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[[Category: Oleksy, A]]
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[[Category: Miller S]]
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[[Category: Perisic, O]]
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[[Category: Oleksy A]]
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[[Category: Shokat, K M]]
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[[Category: Perisic O]]
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[[Category: Tavshanjian, B]]
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[[Category: Shokat KM]]
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[[Category: Williams, R L]]
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[[Category: Tavshanjian B]]
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[[Category: Transferase]]
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[[Category: Williams RL]]

Current revision

THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-90

PDB ID 2x6i

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