This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2x8l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:26, 20 December 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
==PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE APO STRUCTURE==
+
 
-
<StructureSection load='2x8l' size='340' side='right' caption='[[2x8l]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+
==Plasmodium falciparum lactate dehydrogenase apo structure==
 +
<StructureSection load='2x8l' size='340' side='right'caption='[[2x8l]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2x8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8L FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2x8l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8L FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t26|1t26]], [[1t2e|1t2e]], [[2a94|2a94]], [[1t25|1t25]], [[1u5a|1u5a]], [[1u5c|1u5c]], [[1xiv|1xiv]], [[1ldg|1ldg]], [[1t24|1t24]], [[1t2c|1t2c]], [[1cet|1cet]], [[1t2d|1t2d]], [[1u4s|1u4s]], [[1ceq|1ceq]], [[1u4o|1u4o]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8l OCA], [https://pdbe.org/2x8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8l RCSB], [https://www.ebi.ac.uk/pdbsum/2x8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8l ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8l RCSB], [http://www.ebi.ac.uk/pdbsum/2x8l PDBsum]</span></td></tr>
+
</table>
-
<table>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/Q71T02_PLAFA Q71T02_PLAFA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8l_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8l_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x8l ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Lactate Dehydrogenase|Lactate Dehydrogenase]]
+
*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: L-lactate dehydrogenase]]
+
[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
-
[[Category: Birkinshaw, R W.]]
+
[[Category: Birkinshaw RW]]
-
[[Category: Brady, R L.]]
+
[[Category: Brady RL]]
-
[[Category: Glycolysis]]
+
-
[[Category: Nad]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Pyruvate]]
+

Current revision

Plasmodium falciparum lactate dehydrogenase apo structure

PDB ID 2x8l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools