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2xdp
From Proteopedia
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==Crystal structure of the tudor domain of human JMJD2C== | ==Crystal structure of the tudor domain of human JMJD2C== | ||
| - | <StructureSection load='2xdp' size='340' side='right' caption='[[2xdp]], [[Resolution|resolution]] 1.56Å' scene=''> | + | <StructureSection load='2xdp' size='340' side='right'caption='[[2xdp]], [[Resolution|resolution]] 1.56Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xdp]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDP FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdp OCA], [https://pdbe.org/2xdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdp RCSB], [https://www.ebi.ac.uk/pdbsum/2xdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KDM4C_HUMAN KDM4C_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdp_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdp_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[Jumonji domain-containing protein|Jumonji domain-containing protein]] | + | *[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Allerston | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Allerston C]] |
| - | [[Category: Bountra | + | [[Category: Arrowsmith C]] |
| - | [[Category: Chaikuad | + | [[Category: Bountra C]] |
| - | [[Category: Daniel | + | [[Category: Chaikuad A]] |
| - | + | [[Category: Daniel M]] | |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi C]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Phillips | + | [[Category: Phillips C]] |
| - | [[Category: Ugochukwu | + | [[Category: Ugochukwu E]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Weisbach | + | [[Category: Weisbach H]] |
| - | [[Category: Yue | + | [[Category: Yue WW]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
| - | + | ||
Current revision
Crystal structure of the tudor domain of human JMJD2C
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Categories: Homo sapiens | Large Structures | Allerston C | Arrowsmith C | Bountra C | Chaikuad A | Daniel M | Edwards A | Gileadi C | Krojer T | Oppermann U | Phillips C | Ugochukwu E | Weigelt J | Weisbach H | Yue WW | Von Delft F
