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2xed

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==Nocardia farcinica maleate cis-trans isomerase C194S mutant with a covalently bound succinylcysteine intermediate==
==Nocardia farcinica maleate cis-trans isomerase C194S mutant with a covalently bound succinylcysteine intermediate==
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<StructureSection load='2xed' size='340' side='right' caption='[[2xed]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='2xed' size='340' side='right'caption='[[2xed]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xed]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nocfa Nocfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XED FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xed]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nocardia_farcinica_IFM_10152 Nocardia farcinica IFM 10152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XED FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xec|2xec]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xed OCA], [https://pdbe.org/2xed PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xed RCSB], [https://www.ebi.ac.uk/pdbsum/2xed PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xed ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xed OCA], [http://pdbe.org/2xed PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xed RCSB], [http://www.ebi.ac.uk/pdbsum/2xed PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xed ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAIA_NOCFA MAIA_NOCFA] Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. Shows a strict specificity for maleate, with no activity detected toward structurally related substrates including citraconate, mesaconate, dimethylmaleate, and maleamide.<ref>PMID:20677745</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Maleate isomerase]]
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[[Category: Large Structures]]
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[[Category: Nocfa]]
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[[Category: Nocardia farcinica IFM 10152]]
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[[Category: Baudendistel, N]]
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[[Category: Baudendistel N]]
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[[Category: Bruce, N C]]
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[[Category: Bruce NC]]
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[[Category: Fisch, F]]
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[[Category: Fisch F]]
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[[Category: Grogan, G]]
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[[Category: Grogan G]]
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[[Category: Hart, S]]
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[[Category: Hart S]]
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[[Category: Hauer, B]]
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[[Category: Hauer B]]
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[[Category: Martinez-Fleites, C]]
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[[Category: Martinez-Fleites C]]
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[[Category: Turkenburg, J P]]
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[[Category: Turkenburg JP]]
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[[Category: Cofactor-independent cis-trans isomerase]]
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[[Category: Isomerase]]
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[[Category: Nicotinic acid catabolism]]
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Current revision

Nocardia farcinica maleate cis-trans isomerase C194S mutant with a covalently bound succinylcysteine intermediate

PDB ID 2xed

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