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2xga

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==MTSL SPIN-LABELLED SHIGELLA FLEXNERI SPA15==
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==MTSL spin-labelled Shigella Flexneri Spa15==
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<StructureSection load='2xga' size='340' side='right' caption='[[2xga]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='2xga' size='340' side='right'caption='[[2xga]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XGA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xga]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XGA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTN:S-[(1-OXYL-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL]+METHANESULFONOTHIOATE'>MTN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ry9|1ry9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTN:S-[(1-OXYL-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL]+METHANESULFONOTHIOATE'>MTN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xga OCA], [http://pdbe.org/2xga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xga RCSB], [http://www.ebi.ac.uk/pdbsum/2xga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xga ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xga OCA], [https://pdbe.org/2xga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xga RCSB], [https://www.ebi.ac.uk/pdbsum/2xga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xga ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPAK_SHIFL SPAK_SHIFL]] Required for surface presentation of invasion plasmid antigens. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone IpaA, IpgB1, OspC3 and probably also OspB.
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[https://www.uniprot.org/uniprot/SPAK_SHIFL SPAK_SHIFL] Required for surface presentation of invasion plasmid antigens. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone IpaA, IpgB1, OspC3 and probably also OspB.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Shigella paradysenteriae weldin 1927]]
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[[Category: Large Structures]]
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[[Category: Johnson, S]]
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[[Category: Shigella flexneri]]
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[[Category: Lea, S M]]
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[[Category: Johnson S]]
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[[Category: Lillington, J E.D]]
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[[Category: Lea SM]]
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[[Category: Chaperone]]
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[[Category: Lillington JED]]
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[[Category: Virulence factor]]
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Current revision

MTSL spin-labelled Shigella Flexneri Spa15

PDB ID 2xga

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