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2xh1

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==Crystal structure of human KAT II-inhibitor complex==
==Crystal structure of human KAT II-inhibitor complex==
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<StructureSection load='2xh1' size='340' side='right' caption='[[2xh1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2xh1' size='340' side='right'caption='[[2xh1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XH1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xh1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XH1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BF5:(3S)-10-(4-AMINOPIPERAZIN-1-YL)-9-FLUORO-7-HYDROXY-3-METHYL-2,3-DIHYDRO-8H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLATE'>BF5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vgz|2vgz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BF5:(3S)-10-(4-AMINOPIPERAZIN-1-YL)-9-FLUORO-7-HYDROXY-3-METHYL-2,3-DIHYDRO-8H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLATE'>BF5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xh1 OCA], [http://pdbe.org/2xh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xh1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xh1 OCA], [https://pdbe.org/2xh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xh1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xh1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
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[https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Casazza, V]]
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[[Category: Large Structures]]
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[[Category: Garavaglia, S]]
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[[Category: Casazza V]]
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[[Category: Kajii, Y]]
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[[Category: Garavaglia S]]
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[[Category: Kojima, S I]]
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[[Category: Kajii Y]]
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[[Category: Okuwaki, K]]
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[[Category: Kojima SI]]
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[[Category: Ono, S I]]
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[[Category: Okuwaki K]]
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[[Category: Rizzi, M]]
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[[Category: Ono SI]]
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[[Category: Rossi, F]]
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[[Category: Rizzi M]]
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[[Category: Sathyasaikumar, K V]]
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[[Category: Rossi F]]
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[[Category: Schwarcz, R]]
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[[Category: Sathyasaikumar KV]]
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[[Category: Covalent inhibition]]
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[[Category: Schwarcz R]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human KAT II-inhibitor complex

PDB ID 2xh1

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