2xu3

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<StructureSection load='2xu3' size='340' side='right'caption='[[2xu3]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
<StructureSection load='2xu3' size='340' side='right'caption='[[2xu3]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cjl|1cjl]], [[1mhw|1mhw]], [[1cs8|1cs8]], [[2vhs|2vhs]], [[1icf|1icf]], [[2xu5|2xu5]], [[2xu4|2xu4]], [[2xu1|2xu1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [https://pdbe.org/2xu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [http://pdbe.org/2xu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.
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[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin L]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Banner, D W]]
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[[Category: Banner DW]]
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[[Category: Benz, J M]]
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[[Category: Benz JM]]
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[[Category: Haap, W]]
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[[Category: Haap W]]
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[[Category: Drug design]]
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[[Category: Hydrolase]]
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[[Category: Thiol protease]]
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Current revision

CATHEPSIN L WITH A NITRILE INHIBITOR

PDB ID 2xu3

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