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2xus

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Current revision (10:39, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2xus' size='340' side='right'caption='[[2xus]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='2xus' size='340' side='right'caption='[[2xus]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.912&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [https://pdbe.org/2xus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [https://www.ebi.ac.uk/pdbsum/2xus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [https://pdbe.org/2xus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [https://www.ebi.ac.uk/pdbsum/2xus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BRMS1_HUMAN BRMS1_HUMAN]] Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<ref>PMID:14581478</ref> <ref>PMID:17000776</ref> <ref>PMID:20830743</ref>
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[https://www.uniprot.org/uniprot/BRMS1_HUMAN BRMS1_HUMAN] Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<ref>PMID:14581478</ref> <ref>PMID:17000776</ref> <ref>PMID:20830743</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bravo, J]]
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[[Category: Bravo J]]
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[[Category: Neira, J L]]
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[[Category: Neira JL]]
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[[Category: Ortiz-Lombardia, M]]
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[[Category: Ortiz-Lombardia M]]
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[[Category: Rivera, J]]
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[[Category: Rivera J]]
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[[Category: Romero, A]]
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[[Category: Romero A]]
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[[Category: Spinola-Amilibia, M]]
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[[Category: Spinola-Amilibia M]]
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[[Category: Breast cancer metastasis]]
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[[Category: Protein binding]]
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Current revision

Crystal Structure of the BRMS1 N-terminal region

PDB ID 2xus

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