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2y3p

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==CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF GYRA WITH THE ANTIBIOTIC SIMOCYCLINONE D8==
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<StructureSection load='2y3p' size='340' side='right' caption='[[2y3p]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
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==Crystal structure of N-terminal domain of GyrA with the antibiotic simocyclinone D8==
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<StructureSection load='2y3p' size='340' side='right'caption='[[2y3p]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y3p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2wl2 2wl2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y3P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2wl2 2wl2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y3P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SM8:SIMOCYCLINONE+D8'>SM8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SM8:SIMOCYCLINONE+D8'>SM8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y3p RCSB], [http://www.ebi.ac.uk/pdbsum/2y3p PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3p OCA], [https://pdbe.org/2y3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y3p RCSB], [https://www.ebi.ac.uk/pdbsum/2y3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3p ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GYRA_SHIFL GYRA_SHIFL] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2y3p" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Gyrase|Gyrase]]
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Buttner, M J.]]
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[[Category: Large Structures]]
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[[Category: Clarke, T A.]]
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[[Category: Buttner MJ]]
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[[Category: Edwards, M J.]]
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[[Category: Clarke TA]]
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[[Category: Fiedler, H P.]]
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[[Category: Edwards MJ]]
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[[Category: Flatman, R H.]]
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[[Category: Fiedler H-P]]
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[[Category: Lawson, D M.]]
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[[Category: Flatman RH]]
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[[Category: Le, T B.K.]]
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[[Category: Lawson DM]]
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[[Category: Maxwell, A.]]
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[[Category: Le TBK]]
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[[Category: Mckay, A R.]]
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[[Category: Maxwell A]]
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[[Category: Mitchenall, L A.]]
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[[Category: McKay AR]]
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[[Category: Stevenson, C E.M.]]
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[[Category: Mitchenall LA]]
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[[Category: Aminocoumarin antibiotic]]
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[[Category: Stevenson CEM]]
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[[Category: Isomerase]]
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Current revision

Crystal structure of N-terminal domain of GyrA with the antibiotic simocyclinone D8

PDB ID 2y3p

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