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2yds

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==CpOGA D298N in complex with TAB1-derived O-GlcNAc peptide==
==CpOGA D298N in complex with TAB1-derived O-GlcNAc peptide==
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<StructureSection load='2yds' size='340' side='right' caption='[[2yds]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='2yds' size='340' side='right'caption='[[2yds]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yds]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YDS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YDS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yds]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YDS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cbi|2cbi]], [[2yiy|2yiy]], [[2vur|2vur]], [[2x0y|2x0y]], [[2xpk|2xpk]], [[2j62|2j62]], [[2wb5|2wb5]], [[2jh2|2jh2]], [[2j4o|2j4o]], [[2v5c|2v5c]], [[2cbj|2cbj]], [[2ydq|2ydq]], [[2v5d|2v5d]], [[2ydr|2ydr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_O-GlcNAcase Protein O-GlcNAcase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.169 3.2.1.169] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yds OCA], [https://pdbe.org/2yds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yds RCSB], [https://www.ebi.ac.uk/pdbsum/2yds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yds ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yds OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yds RCSB], [http://www.ebi.ac.uk/pdbsum/2yds PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OGA_CLOP1 OGA_CLOP1]] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins. [[http://www.uniprot.org/uniprot/TAB1_HUMAN TAB1_HUMAN]] May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.<ref>PMID:16879102</ref>
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[https://www.uniprot.org/uniprot/OGA_CLOP1 OGA_CLOP1] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2yds" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[O-GlcNAcase|O-GlcNAcase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Clostridium perfringens]]
[[Category: Clostridium perfringens]]
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[[Category: Protein O-GlcNAcase]]
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[[Category: Homo sapiens]]
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[[Category: Aalten, D M.F Van]]
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[[Category: Large Structures]]
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[[Category: Borodkin, V S]]
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[[Category: Borodkin VS]]
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[[Category: Gray, L J]]
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[[Category: Gray LJ]]
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[[Category: Schimpl, M]]
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[[Category: Schimpl M]]
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[[Category: Cell adhesion]]
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[[Category: Van Aalten DMF]]
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[[Category: Hydrolase-peptide complex]]
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[[Category: Metal binding]]
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Current revision

CpOGA D298N in complex with TAB1-derived O-GlcNAc peptide

PDB ID 2yds

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