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2yfw

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Current revision (10:51, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2yfw' size='340' side='right'caption='[[2yfw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2yfw' size='340' side='right'caption='[[2yfw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yfw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YFW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yfw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YFW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yfv|2yfv]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yfw OCA], [https://pdbe.org/2yfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yfw RCSB], [https://www.ebi.ac.uk/pdbsum/2yfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yfw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yfw OCA], [https://pdbe.org/2yfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yfw RCSB], [https://www.ebi.ac.uk/pdbsum/2yfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yfw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CENPA_KLULA CENPA_KLULA]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). [[https://www.uniprot.org/uniprot/Q6CMU6_KLULA Q6CMU6_KLULA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).[SAAS:SAAS00202799]
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[https://www.uniprot.org/uniprot/CENPA_KLULA CENPA_KLULA] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Candida sphaerica]]
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[[Category: Kluyveromyces lactis NRRL Y-1140]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cho, U S]]
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[[Category: Cho US]]
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[[Category: Harrison, S C]]
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[[Category: Harrison SC]]
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[[Category: Budding yeast]]
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[[Category: Cell cycle]]
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[[Category: Centromere]]
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[[Category: Histone chaperone]]
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[[Category: Kinetochore]]
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Current revision

Heterotetramer structure of Kluyveromyces lactis Cse4,H4

PDB ID 2yfw

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