2ylh

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[[Image:2ylh.jpg|left|200px]]
 
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==Structure of N-terminal domain of Candida albicans Als9-2 G299W mutant==
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The line below this paragraph, containing "STRUCTURE_2ylh", creates the "Structure Box" on the page.
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<StructureSection load='2ylh' size='340' side='right'caption='[[2ylh]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ylh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ylh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ylh OCA], [https://pdbe.org/2ylh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ylh RCSB], [https://www.ebi.ac.uk/pdbsum/2ylh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ylh ProSAT]</span></td></tr>
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{{STRUCTURE_2ylh| PDB=2ylh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALS9_CANAL ALS9_CANAL] Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections (PubMed:17510860, PubMed:22321066, PubMed:22429754). Allele ALS9-2 contributes to endothelial cell adhesion, whereas ALS9-1 does not (PubMed:17600078).<ref>PMID:17510860</ref> <ref>PMID:17600078</ref> <ref>PMID:22321066</ref> <ref>PMID:22429754</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Candida albicans is the most prevalent fungal pathogen in humans and a major source of life-threatening nosocomial infections. The Als (agglutinin-like sequence) glycoproteins are an important virulence factor for this fungus and have been associated with binding of host-cell surface proteins and small peptides of random sequence, the formation of biofilms and amyloid fibers. High-resolution structures of N-terminal Als adhesins (NT-Als; up to 314 amino acids) show that ligand recognition relies on a motif capable of binding flexible C termini of peptides in extended conformation. Central to this mechanism is an invariant lysine that recognizes the C-terminal carboxylate of ligands at the end of a deep-binding cavity. In addition to several protein-peptide interactions, a network of water molecules runs parallel to one side of the ligand and contributes to the recognition of diverse peptide sequences. These data establish NT-Als adhesins as a separate family of peptide-binding proteins and an unexpected adhesion system for primary, widespread protein-protein interactions at the Candida/host-cell interface.
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===STRUCTURE OF N-TERMINAL DOMAIN OF CANDIDA ALBICANS ALS9-2 G299W MUTANT===
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Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans.,Salgado PS, Yan R, Taylor JD, Burchell L, Jones R, Hoyer LL, Matthews SJ, Simpson PJ, Cota E Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15775-9. Epub 2011 Sep 6. PMID:21896717<ref>PMID:21896717</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ylh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21896717 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21896717}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2ylh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLH OCA].
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==Reference==
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<ref group="xtra">PMID:021896717</ref><references group="xtra"/>
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[[Category: Candida albicans]]
[[Category: Candida albicans]]
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[[Category: Burchell, L.]]
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[[Category: Large Structures]]
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[[Category: Cota, E.]]
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[[Category: Burchell L]]
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[[Category: Salgado, P S.]]
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[[Category: Cota E]]
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[[Category: Adhesin]]
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[[Category: Salgado PS]]
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[[Category: Cell adhesion]]
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[[Category: Peptide-binding protein]]
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Current revision

Structure of N-terminal domain of Candida albicans Als9-2 G299W mutant

PDB ID 2ylh

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