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3zlr

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==Crystal structure of BCL-XL in complex with inhibitor (WEHI-539)==
==Crystal structure of BCL-XL in complex with inhibitor (WEHI-539)==
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<StructureSection load='3zlr' size='340' side='right' caption='[[3zlr]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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<StructureSection load='3zlr' size='340' side='right'caption='[[3zlr]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zlr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZLR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zlr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZLR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X0B:5-[3-[4-(AMINOMETHYL)PHENOXY]PROPYL]-2-[(8E)-8-(1,3-BENZOTHIAZOL-2-YLHYDRAZINYLIDENE)-6,7-DIHYDRO-5H-NAPHTHALEN-2-YL]-1,3-THIAZOLE-4-CARBOXYLIC+ACID'>X0B</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.026&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zln|3zln]], [[3zlo|3zlo]], [[3zk6|3zk6]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X0B:5-[3-[4-(AMINOMETHYL)PHENOXY]PROPYL]-2-[(8E)-8-(1,3-BENZOTHIAZOL-2-YLHYDRAZINYLIDENE)-6,7-DIHYDRO-5H-NAPHTHALEN-2-YL]-1,3-THIAZOLE-4-CARBOXYLIC+ACID'>X0B</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zlr OCA], [http://pdbe.org/3zlr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zlr RCSB], [http://www.ebi.ac.uk/pdbsum/3zlr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zlr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zlr OCA], [https://pdbe.org/3zlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zlr RCSB], [https://www.ebi.ac.uk/pdbsum/3zlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zlr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[B-cell lymphoma protein|B-cell lymphoma protein]]
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Colman, P M]]
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[[Category: Large Structures]]
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[[Category: Czabotar, P E]]
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[[Category: Colman PM]]
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[[Category: Lessene, G L]]
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[[Category: Czabotar PE]]
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[[Category: Smith, B J]]
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[[Category: Lessene GL]]
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[[Category: Apoptosis]]
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[[Category: Smith BJ]]
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[[Category: Inhibitor]]
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Current revision

Crystal structure of BCL-XL in complex with inhibitor (WEHI-539)

PDB ID 3zlr

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