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3zpq

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<StructureSection load='3zpq' size='340' side='right'caption='[[3zpq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3zpq' size='340' side='right'caption='[[3zpq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zpq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZPQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zpq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZPQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XF5:4-(PIPERAZIN-1-YL)-1H-INDOLE'>XF5</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zpr|3zpr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XF5:4-(PIPERAZIN-1-YL)-1H-INDOLE'>XF5</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpq OCA], [http://pdbe.org/3zpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zpq RCSB], [http://www.ebi.ac.uk/pdbsum/3zpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zpq OCA], [https://pdbe.org/3zpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zpq RCSB], [https://www.ebi.ac.uk/pdbsum/3zpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zpq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
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[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Melga]]
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[[Category: Meleagris gallopavo]]
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[[Category: Brown, J]]
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[[Category: Brown J]]
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[[Category: Christopher, J A]]
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[[Category: Christopher JA]]
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[[Category: Congreve, M]]
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[[Category: Congreve M]]
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[[Category: Dore, A S]]
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[[Category: Dore AS]]
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[[Category: Errey, J C]]
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[[Category: Errey JC]]
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[[Category: Koglin, M]]
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[[Category: Koglin M]]
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[[Category: Marshall, F H]]
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[[Category: Marshall FH]]
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[[Category: Myszka, D G]]
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[[Category: Myszka DG]]
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[[Category: Tate, C G]]
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[[Category: Tate CG]]
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[[Category: Tehan, B]]
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[[Category: Tehan B]]
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[[Category: Warne, T]]
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[[Category: Warne T]]
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[[Category: Aryl piperazine]]
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[[Category: Fragment screening]]
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[[Category: Gpcr]]
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[[Category: Membrane protein]]
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[[Category: Structure based drug design]]
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Current revision

Thermostabilised turkey beta1 adrenergic receptor with 4-(piperazin-1- yl)-1H-indole bound (compound 19)

PDB ID 3zpq

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