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3zv2

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==HUMAN PROTEIN-TYROSINE PHOSPHATASE 1B C215A, S216A MUTANT==
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==Human protein-tyrosine phosphatase 1b C215A, S216A mutant==
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<StructureSection load='3zv2' size='340' side='right' caption='[[3zv2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='3zv2' size='340' side='right'caption='[[3zv2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zv2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV2 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f6t|2f6t]], [[2f6f|2f6f]], [[2cnf|2cnf]], [[2cm3|2cm3]], [[1g1f|1g1f]], [[2cm2|2cm2]], [[1q6n|1q6n]], [[1ptu|1ptu]], [[1c84|1c84]], [[2veu|2veu]], [[1nz7|1nz7]], [[1q1m|1q1m]], [[2azr|2azr]], [[1c88|1c88]], [[1oet|1oet]], [[1c83|1c83]], [[1sug|1sug]], [[1onz|1onz]], [[1g1g|1g1g]], [[1xbo|1xbo]], [[1ptv|1ptv]], [[2cnh|2cnh]], [[2hnp|2hnp]], [[1nwl|1nwl]], [[1t49|1t49]], [[2f6y|2f6y]], [[2cne|2cne]], [[1nl9|1nl9]], [[1c86|1c86]], [[1kav|1kav]], [[2hnq|2hnq]], [[1jf7|1jf7]], [[1pxh|1pxh]], [[1q6s|1q6s]], [[1l8g|1l8g]], [[2cma|2cma]], [[1q6m|1q6m]], [[1bzj|1bzj]], [[1i57|1i57]], [[1wax|1wax]], [[1ony|1ony]], [[1g1h|1g1h]], [[1kak|1kak]], [[2cng|2cng]], [[1t4j|1t4j]], [[2cni|2cni]], [[2b07|2b07]], [[2cm8|2cm8]], [[1eeo|1eeo]], [[1g7g|1g7g]], [[1ptt|1ptt]], [[1qxk|1qxk]], [[1ecv|1ecv]], [[1oem|1oem]], [[1nwe|1nwe]], [[2cmb|2cmb]], [[2fjn|2fjn]], [[1aax|1aax]], [[2vev|2vev]], [[2vey|2vey]], [[2b4s|2b4s]], [[2cm7|2cm7]], [[2bgd|2bgd]], [[1a5y|1a5y]], [[2vex|2vex]], [[1c85|1c85]], [[2cmc|2cmc]], [[2vew|2vew]], [[1lqf|1lqf]], [[2f6w|2f6w]], [[1c87|1c87]], [[1no6|1no6]], [[1pyn|1pyn]], [[2bge|2bge]], [[1oes|1oes]], [[1bzc|1bzc]], [[2f6z|2f6z]], [[2f71|2f71]], [[1oeu|1oeu]], [[1q6t|1q6t]], [[1g7f|1g7f]], [[1nny|1nny]], [[1q6j|1q6j]], [[2f70|2f70]], [[1q6p|1q6p]], [[2f6v|2f6v]], [[1t48|1t48]], [[1oeo|1oeo]], [[2fjm|2fjm]], [[1pa1|1pa1]], [[1ph0|1ph0]], [[1bzh|1bzh]], [[1gfy|1gfy]], [[1een|1een]], [[1pty|1pty]], [[1oev|1oev]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv2 OCA], [https://pdbe.org/3zv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv2 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv2 OCA], [http://pdbe.org/3zv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zv2 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Barford, D]]
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[[Category: Barford D]]
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[[Category: Salmeen, A]]
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[[Category: Salmeen A]]
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[[Category: Tonks, N K]]
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[[Category: Tonks NK]]
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[[Category: Hydrolase]]
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[[Category: Phosphorylation]]
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Current revision

Human protein-tyrosine phosphatase 1b C215A, S216A mutant

PDB ID 3zv2

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