3zzw

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[[Image:3zzw.jpg|left|200px]]
 
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==Crystal structure of the kinase domain of ROR2==
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The line below this paragraph, containing "STRUCTURE_3zzw", creates the "Structure Box" on the page.
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<StructureSection load='3zzw' size='340' side='right'caption='[[3zzw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZZW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3zzw| PDB=3zzw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zzw OCA], [https://pdbe.org/3zzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zzw RCSB], [https://www.ebi.ac.uk/pdbsum/3zzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zzw ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF ROR2===
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== Disease ==
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[https://www.uniprot.org/uniprot/ROR2_HUMAN ROR2_HUMAN] Autosomal recessive Robinow syndrome;Brachydactyly type B. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/ROR2_HUMAN ROR2_HUMAN] Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.<ref>PMID:17717073</ref>
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[[3zzw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZZW OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund, H.]]
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[[Category: Berglund H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Ekblad, T.]]
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[[Category: Ekblad T]]
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[[Category: Graslund, S.]]
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[[Category: Graslund S]]
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[[Category: Karlberg, T.]]
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[[Category: Karlberg T]]
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[[Category: Moche, M.]]
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[[Category: Moche M]]
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[[Category: Nordlund, P.]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T.]]
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[[Category: Nyman T]]
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[[Category: Schuler, H.]]
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[[Category: Schuler H]]
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[[Category: Sgc, Structural Genomics Consortium.]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Kinase]]
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[[Category: Neurotrophic tyrosine kinase]]
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[[Category: Ntrkr2]]
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[[Category: Receptor-related 2]]
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[[Category: Ror2]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the kinase domain of ROR2

PDB ID 3zzw

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