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4ao5

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Current revision (11:31, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4ao5' size='340' side='right'caption='[[4ao5]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4ao5' size='340' side='right'caption='[[4ao5]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ao5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AO5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ao5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AO5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2baz|2baz]], [[2xx6|2xx6]], [[2xy3|2xy3]], [[2y1t|2y1t]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ao5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ao5 OCA], [https://pdbe.org/4ao5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ao5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ao5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ao5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ao5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ao5 OCA], [https://pdbe.org/4ao5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ao5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ao5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ao5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/YOSS_BACSU YOSS_BACSU]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
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[https://www.uniprot.org/uniprot/YOSS_BACSU YOSS_BACSU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Vibrio subtilis ehrenberg 1835]]
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[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: DUTP diphosphatase]]
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[[Category: Garcia-Nafria J]]
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[[Category: Garcia-Nafria, J]]
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[[Category: Harrison C]]
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[[Category: Harrison, C]]
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[[Category: Turkenburg JP]]
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[[Category: Turkenburg, J P]]
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[[Category: Wilson KS]]
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[[Category: Wilson, K S]]
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[[Category: Homotrimeric dutpase]]
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[[Category: Hydrolase]]
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[[Category: Phe-lid]]
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Current revision

B. subtilis prophage dUTPase YosS in complex with dUMP

PDB ID 4ao5

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