This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4apy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:32, 20 December 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis==
==Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis==
-
<StructureSection load='4apy' size='340' side='right' caption='[[4apy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='4apy' size='340' side='right'caption='[[4apy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4apy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4apy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APY FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4apy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4apy RCSB], [http://www.ebi.ac.uk/pdbsum/4apy PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apy OCA], [https://pdbe.org/4apy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apy RCSB], [https://www.ebi.ac.uk/pdbsum/4apy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apy ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CP125_MYCS2 CP125_MYCS2] Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.<ref>PMID:23489718</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 14: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4apy" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Mycobacterium smegmatis]]
+
[[Category: Large Structures]]
-
[[Category: Fernandez, E Garcia]]
+
[[Category: Mycolicibacterium smegmatis MC2 155]]
-
[[Category: Frank, D J]]
+
[[Category: Frank DJ]]
-
[[Category: Kells, P M]]
+
[[Category: Garcia Fernandez E]]
-
[[Category: Lopez, J L.Garcia]]
+
[[Category: Garcia Lopez JL]]
-
[[Category: Montellano, P R.Ortiz de]]
+
[[Category: Kells PM]]
-
[[Category: Podust, L M]]
+
[[Category: Ortiz de Montellano PR]]
-
[[Category: Cholesterol metabolism]]
+
[[Category: Podust LM]]
-
[[Category: Oxidoreductase]]
+

Current revision

Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis

PDB ID 4apy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4apy"
Personal tools