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4asx
From Proteopedia
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| - | ==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with | + | |
| - | <StructureSection load='4asx' size='340' side='right' caption='[[4asx]], [[Resolution|resolution]] 2.05Å' scene=''> | + | ==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C== |
| + | <StructureSection load='4asx' size='340' side='right'caption='[[4asx]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4asx]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4asx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OJ:7,8-BIS(CHLORANYL)-9-METHYL-3,4-DIHYDRO-2H-PYRIDO[3,4-B]INDOL-1-ONE'>6OJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OJ:7,8-BIS(CHLORANYL)-9-METHYL-3,4-DIHYDRO-2H-PYRIDO[3,4-B]INDOL-1-ONE'>6OJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asx OCA], [https://pdbe.org/4asx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asx RCSB], [https://www.ebi.ac.uk/pdbsum/4asx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asx ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Beltrami | + | [[Category: Beltrami A]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Bracher | + | [[Category: Bracher F]] |
| - | [[Category: Bullock | + | [[Category: Bullock A]] |
| - | [[Category: Canning | + | [[Category: Canning P]] |
| - | [[Category: Chaikuad | + | [[Category: Chaikuad A]] |
| - | [[Category: Cooper | + | [[Category: Cooper CDO]] |
| - | + | [[Category: Edwards AM]] | |
| - | [[Category: Edwards | + | [[Category: Kochan G]] |
| - | [[Category: Kochan | + | [[Category: Krojer T]] |
| - | [[Category: Krojer | + | [[Category: Mahajan P]] |
| - | [[Category: Mahajan | + | [[Category: Pohl B]] |
| - | [[Category: Pohl | + | [[Category: Williams E]] |
| - | [[Category: Williams | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Beltrami A | Bountra C | Bracher F | Bullock A | Canning P | Chaikuad A | Cooper CDO | Edwards AM | Kochan G | Krojer T | Mahajan P | Pohl B | Williams E | Von Delft F
