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4avx

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[[Image:4avx.jpg|left|200px]]
 
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==Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) bound to an IP2 compound at 1.68 A Resolution==
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The line below this paragraph, containing "STRUCTURE_4avx", creates the "Structure Box" on the page.
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<StructureSection load='4avx' size='340' side='right'caption='[[4avx]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4avx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AVX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ITP:PHOSPHORIC+ACID+MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL)+ESTER'>ITP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_4avx| PDB=4avx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4avx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4avx OCA], [https://pdbe.org/4avx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4avx RCSB], [https://www.ebi.ac.uk/pdbsum/4avx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4avx ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of the Tandem Vhs and Fyve Domains of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) bound to an IP2 compound at 1.68 A Resolution===
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== Function ==
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[https://www.uniprot.org/uniprot/HGS_HUMAN HGS_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4avx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVX OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bullock, A.]]
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[[Category: Bountra C]]
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[[Category: Canning, P.]]
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[[Category: Bullock A]]
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[[Category: Conway, S.]]
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[[Category: Canning P]]
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[[Category: Delft, F Von.]]
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[[Category: Conway S]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Shrestha, L.]]
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[[Category: Shrestha L]]
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[[Category: Slowey, A.]]
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[[Category: Slowey A]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Williams, E.]]
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[[Category: Williams E]]
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[[Category: Sgc]]
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[[Category: Von Delft F]]
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[[Category: Signaling]]
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[[Category: Signaling protein]]
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[[Category: Structural genomics consortium]]
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Current revision

Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) bound to an IP2 compound at 1.68 A Resolution

PDB ID 4avx

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