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4aw2

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'''Unreleased structure'''
 
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The entry 4aw2 is ON HOLD
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==Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)==
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<StructureSection load='4aw2' size='340' side='right'caption='[[4aw2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4aw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AW2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22E:5,11-DIMETHYL-1-OXO-2,6-DIHYDRO-1H-PYRIDO[4,3-B]CARBAZOL-9-YL+BENZOATE'>22E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aw2 OCA], [https://pdbe.org/4aw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aw2 RCSB], [https://www.ebi.ac.uk/pdbsum/4aw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aw2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MRCKA_RAT MRCKA_RAT] Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.<ref>PMID:18854160</ref> <ref>PMID:21457715</ref> <ref>PMID:9418861</ref>
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Authors: Elkins, J.M., Muniz, J.R.C., Tan, I., Leung, T., Abdul Azeez, K., Szklarz, M., Phillips, C., Wang, J., VonDelft, F., Bountra, C., Edwards, A., Knapp, S.
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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Description: Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Abdul Azeez K]]
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[[Category: Bountra C]]
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[[Category: Edwards A]]
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[[Category: Elkins JM]]
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[[Category: Knapp S]]
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[[Category: Lafanechere L]]
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[[Category: Leung T]]
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[[Category: Muniz JRC]]
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[[Category: Phillips C]]
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[[Category: Prudent R]]
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[[Category: Szklarz M]]
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[[Category: Tan I]]
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[[Category: Wang J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)

PDB ID 4aw2

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OCA

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