4azc

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==Differential inhibition of the tandem GH20 catalytic modules in the pneumococcal exo-beta-D-N-acetylglucosaminidase, StrH==
==Differential inhibition of the tandem GH20 catalytic modules in the pneumococcal exo-beta-D-N-acetylglucosaminidase, StrH==
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<StructureSection load='4azc' size='340' side='right' caption='[[4azc]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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<StructureSection load='4azc' size='340' side='right'caption='[[4azc]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4azc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AZC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4azc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AZC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NGW:(2S,3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-METHYL-2,3A,5,6,7,7A-HEXAHYDRO-1H-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>NGW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yl5|2yl5]], [[2yl6|2yl6]], [[2yl8|2yl8]], [[2yl9|2yl9]], [[2yla|2yla]], [[2yll|2yll]], [[4az5|4az5]], [[4az6|4az6]], [[4az7|4az7]], [[4azb|4azb]], [[4azg|4azg]], [[4azh|4azh]], [[4azi|4azi]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NGW:(2S,3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-METHYL-2,3A,5,6,7,7A-HEXAHYDRO-1H-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>NGW</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4azc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4azc RCSB], [http://www.ebi.ac.uk/pdbsum/4azc PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4azc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azc OCA], [https://pdbe.org/4azc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4azc RCSB], [https://www.ebi.ac.uk/pdbsum/4azc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4azc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STRH_STRPN STRH_STRPN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4azc" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
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*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
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*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Strpn]]
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[[Category: Large Structures]]
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[[Category: Boraston, A B]]
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Pluvinage, B]]
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[[Category: Boraston AB]]
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[[Category: Stubbs, K A]]
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[[Category: Pluvinage B]]
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[[Category: Vocadlo, D J]]
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[[Category: Stubbs KA]]
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[[Category: Hydrolase]]
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[[Category: Vocadlo DJ]]

Current revision

Differential inhibition of the tandem GH20 catalytic modules in the pneumococcal exo-beta-D-N-acetylglucosaminidase, StrH

PDB ID 4azc

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