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4b2b

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[[Image:4b2b.jpg|left|200px]]
 
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{{STRUCTURE_4b2b| PDB=4b2b | SCENE= }}
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==Structure of the factor Xa-like trypsin variant triple-Ala (TGPA) in complex with eglin C==
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<StructureSection load='4b2b' size='340' side='right'caption='[[4b2b]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4b2b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2b OCA], [https://pdbe.org/4b2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2b RCSB], [https://www.ebi.ac.uk/pdbsum/4b2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Abstract The energetics of macromolecular interactions are complex, particularly where protein flexibility is involved. Exploiting serendipitous differences in the plasticity of a series of closely related trypsin variants, we analyzed the enthalpic and entropic contributions accompanying interaction with L45K-eglin C. Binding of the four variants show significant differences in released heat, although the affinities vary little, in accordance with the principle of enthalpy-entropy compensation. Binding of the most disordered variant is almost entirely enthalpically driven, with practically no entropy change. As structures of the complexes reveal negligible differences in protein-inhibitor contacts, we conclude that solvent effects contribute significantly to binding affinities.
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===Structure of the factor Xa-like trypsin variant triple-Ala (TGPA) in complex with eglin C===
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Thermodynamic signatures in macromolecular interactions involving conformational flexibility.,Menzel A, Neumann P, Schwieger C, Stubbs MT Biol Chem. 2014 Jul 1;395(7-8):905-11. doi: 10.1515/hsz-2014-0177. PMID:25003391<ref>PMID:25003391</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4b2b" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[4b2b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2B OCA].
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*[[Eglin|Eglin]]
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*[[Trypsin 3D structures|Trypsin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Hirudo medicinalis]]
[[Category: Hirudo medicinalis]]
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[[Category: Trypsin]]
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[[Category: Large Structures]]
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[[Category: Menzel, A.]]
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[[Category: Menzel A]]
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[[Category: Neumann, P.]]
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[[Category: Neumann P]]
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[[Category: Stubbs, M T.]]
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[[Category: Stubbs MT]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Structure of the factor Xa-like trypsin variant triple-Ala (TGPA) in complex with eglin C

PDB ID 4b2b

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