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4b4n

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==CPSF6 defines a conserved capsid interface that modulates HIV-1 replication==
==CPSF6 defines a conserved capsid interface that modulates HIV-1 replication==
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<StructureSection load='4b4n' size='340' side='right' caption='[[4b4n]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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<StructureSection load='4b4n' size='340' side='right'caption='[[4b4n]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B4N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B4N FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4n OCA], [http://pdbe.org/4b4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b4n RCSB], [http://www.ebi.ac.uk/pdbsum/4b4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b4n ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.813&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4n OCA], [https://pdbe.org/4b4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b4n RCSB], [https://www.ebi.ac.uk/pdbsum/4b4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b4n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CPSF6_HUMAN CPSF6_HUMAN]] Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:21295486</ref>
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[https://www.uniprot.org/uniprot/A9PKC6_9HIV1 A9PKC6_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: James, L C]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Price, A J]]
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[[Category: Large Structures]]
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[[Category: Cyclophilin]]
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[[Category: James LC]]
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[[Category: Hiv-1]]
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[[Category: Price AJ]]
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[[Category: Viral protein-rna binding protein complex]]
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Current revision

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication

PDB ID 4b4n

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