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4b9u

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==Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dA basepair in the post-insertion site.==
==Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dA basepair in the post-insertion site.==
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<StructureSection load='4b9u' size='340' side='right' caption='[[4b9u]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4b9u' size='340' side='right'caption='[[4b9u]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b9u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B9U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b9u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B9U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOX:((1R,2S,4R)-4-{[2-AMINO-5-(FORMYLAMINO)-6-OXO-3,6-DIHYDROPYRIMIDIN-4-YL]AMINO}-2-HYDROXYCYCLOPENTYL)METHYL+5-PHOSPHATE'>FOX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOX:((1R,2S,4R)-4-{[2-AMINO-5-(FORMYLAMINO)-6-OXO-3,6-DIHYDROPYRIMIDIN-4-YL]AMINO}-2-HYDROXYCYCLOPENTYL)METHYL+5-PHOSPHATE'>FOX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xo7|2xo7]], [[2xy5|2xy5]], [[2xy6|2xy6]], [[2xy7|2xy7]], [[2y1i|2y1i]], [[2y1j|2y1j]], [[4b9l|4b9l]], [[4b9m|4b9m]], [[4b9n|4b9n]], [[4b9s|4b9s]], [[4b9t|4b9t]], [[4b9v|4b9v]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9u OCA], [https://pdbe.org/4b9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b9u RCSB], [https://www.ebi.ac.uk/pdbsum/4b9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9u ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b9u OCA], [http://pdbe.org/4b9u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b9u RCSB], [http://www.ebi.ac.uk/pdbsum/4b9u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b9u ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/E1C9K5_GEOSE E1C9K5_GEOSE]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 12980]]
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[[Category: Geobacillus stearothermophilus]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Arnold, S]]
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[[Category: Arnold S]]
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[[Category: Carell, T]]
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[[Category: Carell T]]
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[[Category: Gehrke, T H]]
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[[Category: Gehrke TH]]
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[[Category: Lischke, U]]
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[[Category: Lischke U]]
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[[Category: Schneider, S]]
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[[Category: Schneider S]]
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[[Category: Dna damage]]
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[[Category: Oxidative dna lesion]]
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[[Category: Transferase-dna complex]]
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[[Category: Translesion dna synthesis]]
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Current revision

Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dA basepair in the post-insertion site.

PDB ID 4b9u

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