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4bcd

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==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor==
==PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor==
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<StructureSection load='4bcd' size='340' side='right' caption='[[4bcd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4bcd' size='340' side='right'caption='[[4bcd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BCD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e5t|1e5t]], [[1e8m|1e8m]], [[1e8n|1e8n]], [[1h2w|1h2w]], [[1h2x|1h2x]], [[1h2y|1h2y]], [[1h2z|1h2z]], [[1o6f|1o6f]], [[1o6g|1o6g]], [[1qfm|1qfm]], [[1qfs|1qfs]], [[1uoo|1uoo]], [[1uop|1uop]], [[1uoq|1uoq]], [[1vz2|1vz2]], [[1vz3|1vz3]], [[2xdw|2xdw]], [[4amy|4amy]], [[4amz|4amz]], [[4an0|4an0]], [[4an1|4an1]], [[4ax4|4ax4]], [[4bcb|4bcb]], [[4bcc|4bcc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=TDV:1-[(2S,4S)-4-[4-(4-FLUOROPHENYL)-1,2,3-TRIAZOL-1-YL]-2-PYRROLIDIN-1-YLCARBONYL-PYRROLIDIN-1-YL]-4-PHENYL-BUTAN-1-ONE'>TDV</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [https://pdbe.org/4bcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [https://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bcd OCA], [http://pdbe.org/4bcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bcd RCSB], [http://www.ebi.ac.uk/pdbsum/4bcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bcd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG]] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
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[https://www.uniprot.org/uniprot/PPCE_PIG PPCE_PIG] Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pig]]
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[[Category: Large Structures]]
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[[Category: Prolyl oligopeptidase]]
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[[Category: Sus scrofa]]
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[[Category: Augustyns, K]]
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[[Category: Augustyns K]]
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[[Category: Baekelandt, V]]
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[[Category: Baekelandt V]]
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[[Category: Cheng, J D]]
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[[Category: Cheng JD]]
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[[Category: DeMeester, I]]
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[[Category: DeMeester I]]
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[[Category: Fulop, V]]
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[[Category: Fulop V]]
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[[Category: Gerard, M]]
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[[Category: Gerard M]]
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[[Category: Joossens, J]]
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[[Category: Joossens J]]
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[[Category: Lambeir, A M]]
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[[Category: Lambeir AM]]
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[[Category: Rea, D]]
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[[Category: Rea D]]
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[[Category: VanDerVeken, P]]
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[[Category: VanDerVeken P]]
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[[Category: VanElzen, R]]
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[[Category: VanElzen R]]
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[[Category: Alpha-beta-hydrolase]]
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[[Category: Alzheimers disease]]
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[[Category: Amnesia]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Parkinsons disease]]
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Current revision

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor

PDB ID 4bcd

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