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4bd0

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Current revision (11:48, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4bd0' size='340' side='right'caption='[[4bd0]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
<StructureSection load='4bd0' size='340' side='right'caption='[[4bd0]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bd0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobb Ecobb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BD0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bd0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21 Escherichia coli BL21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BD0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZB:BENZO[B]THIOPHENE-2-BORONIC+ACID'>BZB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.207&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bza|1bza]], [[1iyo|1iyo]], [[1iyp|1iyp]], [[1iyq|1iyq]], [[1iys|1iys]], [[1we4|1we4]], [[2wyx|2wyx]], [[2xqz|2xqz]], [[2xr0|2xr0]], [[4bd1|4bd1]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZB:BENZO[B]THIOPHENE-2-BORONIC+ACID'>BZB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bd0 OCA], [https://pdbe.org/4bd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bd0 RCSB], [https://www.ebi.ac.uk/pdbsum/4bd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bd0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bd0 OCA], [https://pdbe.org/4bd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bd0 RCSB], [https://www.ebi.ac.uk/pdbsum/4bd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bd0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.
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[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX] Has strong cefotaxime-hydrolyzing activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli BL21]]
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[[Category: Ecobb]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Coates, L]]
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[[Category: Coates L]]
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[[Category: Ng, J D]]
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[[Category: Ng JD]]
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[[Category: Ostermann, A]]
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[[Category: Ostermann A]]
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[[Category: Schrader, T E]]
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[[Category: Schrader TE]]
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[[Category: Standaert, R F]]
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[[Category: Standaert RF]]
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[[Category: Tomanicek, S J]]
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[[Category: Tomanicek SJ]]
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[[Category: Weiss, K L]]
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[[Category: Weiss KL]]
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[[Category: Ctx- m-type esbl]]
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[[Category: Extended-spectrum beta lactamase]]
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[[Category: Hydrolase]]
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[[Category: Perdeuterated neutron structure]]
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Current revision

X-ray structure of a perdeuterated Toho-1 R274N R276N double mutant Beta-lactamase in complex with a fully deuterated boronic acid (BZB)

PDB ID 4bd0

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